Activation of Neutrophil Calcium-Dependent and -Independent Phospholipases A2 by Organochlorine Compounds
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چکیده
منابع مشابه
Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2.
The majority of phospholipase A2 activity in myocardium is calcium-independent and selective for hydrolysis of plasmalogen substrate (Wolf, R. A., and Gross, R. W. (1985) J. Biol. Chem. 260, 7295-7303; Hazen, S. L., Stuppy, R. J., and Gross, R. W. (1990) J. Biol. Chem. 265, 10622-10630). Accordingly, identification of an inhibitor which selectively targets calcium-independent phospholipases A2 ...
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Yu, B.-Z., Ghomashchi, F., Cajal, Y., Annand, R. A., Berg, 0. G., Gelb, M. H. and Jain, M. H. (1997) Biochemistry 36, 3870-3881 Bayburt, T., Yu, B. Z., Lin, H. K., Browning, J., Jain, M. K. and Gelb, M. H. (1993) Biochemistry 32, 573-582 Scott, D. L., Mandel, A. M., Sigler, P. B. and Honig, B. (1994) Biophys. J. 67, 493-504 Snitko, Y., Koduri, R. S., Han, S. K., Othman, R., Baker, S. F., Molini...
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Isolated ductal cells of rat submandibular gland phospholipid pools were labeled with [3H]arachidonic acid (AA). The tracer was incorporated preferentially to phosphatidylcholine (46% of the lipidic fraction). Extracellular ATP induced the release of [3H]AA to the extracellular medium in a time- and dose-dependent manner (EC50 = 220 microM). Among other agents tested, only 2', 3'-O-(4-benzoylbe...
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It is suspected that microbial infections take part in the pathogenesis of diabetes mellitus type 1 (T1DM). Glucose-induced insulin secretion is accompanied by the release of free arachidonic acid (AA) mainly by cytosolic- and calcium independent phospholipases A2 (cPLA2 and iPLA2). Insulinoma cell line (INS-1E) was infected with E. coli isolated from the blood culture of a patient with sepsis....
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Calcium has been implicated as a regulatory factor in many physiological and pathophysiological processes in the renal cell. Under physiological conditions, the cytosolic free calcium concentration is maintained at approximately 100 nM. Most of the releasable cell Ca2+ resides in the nonmitochondrial compartments. In addition to the plasma membrane Ca2+ transport processes, there is a high-affi...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2000
ISSN: 1096-0929
DOI: 10.1093/toxsci/53.1.40